Symptoms and Complications
There may be few symptoms at the beginning of the disease. As the air sacs become damaged, shortness of breath with physical activity is usually the first warning sign. As emphysema progresses, you may experience shortness of breath even when you're resting. This can make normal activities such as eating difficult. This can lead to a reduced appetite and weight loss. Other symptoms include chest tightness, fatigue, and chronic cough.
As the air sacs become more stretched, air gets trapped in pockets called bullae that form in the lungs. This can produce a characteristic "barrel chest," which is the shape of the hyperexpanded chest.
Bullae can rupture outside the lung into the pleural space, the space that surrounds the lung. As the air accumulates outside the lung, it may result in a life-threatening condition called pneumothorax. This strains the heart and may cause right-sided heart failure (cor pulmonale). The body will also attempt to compensate for the low oxygen level by increasing the number of red blood cells (secondary polycythemia).